Pharmaceutical applications

GranuHeap instrument as new tool for a fast and easy determination of the flow ability and the cohesion of a granular material (GranuHeap analyses)

GranuHeaP is the first entirely automated instrument able to measure quickly and with high degree of accuracy the repose angle of granular or pulverulent material. Thanks to a simple algorithm, GranuHeaP also measures a cohesive index that provides information on the flow properties of the studied powder. Results are shown for clay, flour, lactose, polymeric and metallic powders.

Ageing study of lactose’s blends by using dynamic compaction curves (GranuPaQ analyses)

Dry powder inhalers (DPI) offer many advantages to the respiratory administration. By targeted effect, the sprayed powders attain higher concentrations in the lungs resulting in a considerable reduced drug dose. This administration is faster than the other kinds of administration. In order to assure the desired drug delivery, the flowability of the blend (mix of carriers and drug) inserted in the pill has been controlled.

Dynamic Tap Density Tester as a useful tool for analyzing pharmaceutical powders (GranuPaQ analyses)

The tap density test is a usefull compressibility tool commonly used in quality control and R&D for developping new formulations.With GranuPack instrument, we are able to categorize more easily the powders with identical or close Hausner ratio Hrand to do a better classification of the powders without any waste of time. In this study different lactoses have been analyzed for determining their flow ability by using new generation of tap density tester. We show that powders with identical Hausner ratio can be categorized with a new index based on the all tap density curve. We can also observe the effect of particle size on the tapping/compressibility kinetic for pharmaceutical powders.

Rheological Study of Blends for Dry Powder Inhalers (DPI) Applications (GranuPaQ and GranuDruM analyses)

The divided solid materials have a considerable share in the products manufactured or used in the pharmaceutical industries (excipients, active pharmaceutical ingredient – API, additives, etc). One of the big challenges of this century is to characterize their various physical behaviours. In this aim, four formulations containing each one a similar excipient (Lactose: L) and two active drugs (A, B or C) were prepared in different ratios (ABL-20-2-5, ABL-20-2-10, ACL-20-2-20 and ABL-20-2-30). These blends are then characterized by using the APTIS instruments : Granupack, Granudrum and Granuheap.